THE EFFECT OF ENDOMETRIAL PATTERN AND THICKNESS ON PREGNANCY RATE IN CONTROLLED OVARIAN HYPERSTIMULATION-INTRAUTERINE INSEMINATION

Objective: In order to evaluate the endometrium by ultrasound in patients undergoing controlled ovarian hyperstimulation (COH) with clomiphene citrate (CC) and human menopausal gonadotropin (HMG) with intrauterine insemination (IUI) to determine the relationship between endometrial pattern and thickness on pregnancy rate (PR). Methods: In this prospective study, 108 infertile couples underwent COH with CC and HMG. The patients were categorized in 4 groups according to etiology. Overall261 COH -IUI cycles with CC-HMG were evaluated. Thickness of the endometrium was measured and its pattern was classified according to its echogenicity. Results: In the homogenous group the pregnancy rate (PR)/cycle was 16. 7%, and in the trilaminar group it was 15 .5%. This difference was not statistically significant (p>0.05). The mean endometrial thickness in trilaminar and homogenous groups was 8.92+ 1.18 mm, and 8. 72+ 1.56 rnrn respectively. In cycles in which conception occurred, the mean endometrial thickness was significantly higher in trilaminar and homogenous groups (p<0.001). In patients with a trilaminar pattern, the pregnancy was equal with those who had a homogenous pattern. The endometrial thickness was a major factor in determining PRs. There was no significant difference between PRs in cycles with trilaminar and homogenous patterns according to the etiology of infertility